The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Background
Differential diagnosis of men with subtypes of non‐obstructive azoospermia (NOA) is important for their treatment. Many genes are transcripted during meiosis. We hypothesized that some of these genes can be detected in cell‐free seminal message RNA (mRNAs) (cfs‐mRNA) and be developed as non‐invasive biomarkers for diagnosing NOA subtypes.
Objective
To screen cfs‐mRNA to diagnose the...
Background
Glucose‐dependent insulinotropic polypeptide receptor (Gipr) gene expression has been reported in mouse spermatids and Gipr knockout male mice have previously been reported to have decreased in vitro fertilization, although the role of Gipr signaling in male mouse fertility is not well understood.
Objectives
The purposes of these studies were to determine the role of glucose‐dependent...
Background
Sleep is a fundamental biological requirement, and lack of sleep has increasingly been recognized to cause metabolic consequences and adversely affect immune function. Recent articles have pointed to how sleep and sexual functions may be interlinked, involving inflammation, vascular alterations, tissue damage, and endothelial dysfunction.
Objectives
We examined the effect of paradoxical...
Background
Tobacco smoking has been reported to cause DNA fragmentation and has been suggested to cause mutations in spermatozoa. These effects have been ascribed to the action of polycyclic aromatic hydrocarbons (PAH) present in the smoke. Simultaneously, DNA fragmentation has been associated with mutagenesis.
Objective
The aim of this study was to investigate whether levels of urinary biomarkers...
Background
Male infertility is a disorder of the reproductive system with a highly complex genetic landscape. In most cases, the reason for male infertility remains unknown; however, the importance of genetic abnormalities in the diagnosis of subfertility/infertility is becoming increasingly recognized. Several syndromes include impaired male fertility in the clinical picture, although a comprehensive...
Background
Necrozoospermia is a condition found in 0.2%–0.4% of male infertility cases. The causes of necrozoospermia are multiple: they can be related to testicular and/or post‐testicular damage. Additionally, these causes most often involve the production of reactive oxygen species (ROS) and/or sperm DNA fragmentation (SDF) which can reduce the chances of spontaneous pregnancy or affect the outcome...
Background
Many cryopreservation carriers have been introduced to freeze rare human spermatozoa, however, these carriers relative attributes and comparative effectivenesses have not yet been systematically studied.
Objectives
Is the micro‐straw cryopreservation carrier more effective for cryopreserving rare human spermatozoa compared with the Cryoplus and a new micro‐straw (LSL straw) carriers?...
Background
The central molecular mechanisms of nonorganic erectile dysfunction remains unknown.
Objective
This study aimed to investigate the association of dopaminergic neurons projecting to the nucleus accumbens of male rats with nonorganic erectile dysfunction.
Materials/methods
Nonorganic erectile dysfunction was induced by chronic mild stress. The sucrose consumption test, sexual behavior...
Background
Human seminal cell‐free deoxyribonucleic acid (cfDNA) methylation patterns have not yet been thoroughly explored; however, recent work in mouse has suggested that some cfDNA encountered in the epididymis may contaminate DNA methylation studies assessing the mature spermatozoa. Such contamination could clearly prove to be a significant confounder, for many reasons, in epigenetic studies...
Introduction
Hyperhomocysteinemia may contribute to the development of endothelial dysfunction and, consequently, atherosclerosis, a systemic disease involving the vessels that may affect the cavernous arteries leading to vasculogenic erectile dysfunction. Our study aims therefore to explore the relationship between homocysteine levels and velocimetric parameters detected by basal penile duplex ultrasound...
Objectives
To investigate clinical outcomes, radiation exposure and procedural costs associated with percutaneous varicocoele embolization using coils and sclerosing agents (SAs) in a cohort of young‐adult men.
Materials and methods
Data from consecutive men treated with percutaneous varicocoele embolization using coils and SA between 2017 and 2021 were analyzed. The allocation was based on a change...
Background
Oxidative stress is one of the leading factors responsible for poor post‐thaw semen quality because of overproduction of reactive oxygen species (ROS) over neutralizing antioxidants present in semen. Mainly two ROS generation sites are present in spermatozoa, that is, mitochondria and plasma membrane. Therefore, the idea of targeting these specific sites for minimization of ROS production...
Background
There are limited data regarding the effects of systemic androgens on late‐stage urethral wound healing.
Objective
To evaluate the effects of systemic androgens on fibrosis and scar formation in late‐stage urethral wound healing.
Materials and methods
Forty‐five male Sprague Dawley rats were divided into three groups. First group consisted of 15 rats that were castrated on 23 days...
Background
Previous meta‐analyses concluded that there is a decline in sperm parameters over time. This conclusion might be incorrect due to inherent biases or focusing only on a single parameter – sperm concentration.
Objective
To study trends in sperm parameters over the past 20 years using data from the trials that defined the reference ranges of the World Health Organization manual.
Materials...
Background
Male hypogonadism (testosterone level < 300 ng/dl) is a clinical syndrome that results from failure of the testis to produce physiological levels of testosterone. Most marketed testosterone replacement therapy products often require multiple dose adjustment clinic visits to achieve the desired, eugonadal testosterone levels.
Objective
To evaluate the efficacy and safety of a novel...
Background
Anogenital distance (AGD), the distance between the anus and genitals, is in rodents a well‐established marker of early androgen action and has been suggested to be so in humans as well. Thus, a link between human AGD and semen quality and potentially fecundity may exist.
Objective
The aim of this study was to assess the association between AGD and male factor infertility and among proven...
Background
The main pathophysiologic conditions of erectile dysfunction (ED) after radical prostatectomy are considered to be corporal fibrosis and apoptosis induced by cavernosal nerve (CN) injury.
Objectives
In a rat model of CN crush injury (CNCI), we investigated whether combination treatment with JNK inhibitor (JNKi), SP600125, and HDAC inhibitor (HDACi), suberoylanilide‐hydroxamic‐7 acid...
Background
Beneficial effects of hyaluronic acid (HA)‐based selection of spermatozoa for intracytoplasmic sperm injection (ICSI) are still controversial, and further studies are needed to categorize patients that might benefit from such a method.
Objective
We investigated whether HA sperm selection improved ICSI outcome of couples with previous ICSI cycle failure.
Materials and methods
In this...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.